Human SPHK1 / Sphingosine Kinase 1 (His & GST Tag) recombinant protein
SPHK1, also known as sphingosine Kinase 1, catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It is a ligand for cell surface G protein-coupled receptors. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation. SPHK1 plays a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes.
Protein short names
SPHINGOSINE KINASE 1; RP23-193A16.4; SK 1; 1110006G24RIK; SPK1; SPHK; SK1; SPHK1; SPK 1
A DNA sequence encoding the human SPHK1 (Q9NYA1-1)(Met1-Leu384) was expressed the N-terminal polyhistidine-tagged GST tag at the N-terminus.
The secreted recombinant human SPHK1 consists of 621 amino acids and predicts a molecular mass of 70.3 KDa. The apparent molecular mass of the protein is approximately 64 KDa in SDS-PAGE under reducing conditions due to glycosylation.
> 95 % as determined by SDS-PAGE
Kinase activity untested
Human SPHK1 / Sphingosine Kinase 1 Protein (His & GST Tag) SDS-PAGE
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