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Product Name
Recombinant HMMR protein (His tag)
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Description
This recombinant protein is a fragment of the human Hyaluronan mediated motility receptor (HMMR), also known as CD168, spanning residues 197-476. It represents a stable and soluble unit ideal for investigating hyaluronic acid-mediated signaling, cell motility, and metastasis-related mechanisms in structural and biochemical studies.
The full-length Hyaluronan mediated motility receptor (HMMR) functions as a receptor for hyaluronic acid and plays a critical role in cell motility. Upon binding hyaluronan, it facilitates the phosphorylation of proteins such as PTK2/FAK1 and may regulate extracellular-regulated kinase (ERK) activity, contributing to cellular transformation, metastasis formation, and adipogenesis. It is localized to the cell surface, cytoplasm, and the cytoskeletal spindle, underscoring its involvement in dynamic cellular processes and signaling pathways.
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Protein name
Hyaluronan mediated motility receptor
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Uniprot ID
O75330
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Gene Name
HMMR; IHABP; RHAMM
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 197-476 aa (O75330) were fused with C-terminal 6His tag.
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Sequence
MSKIKVTQRS LEESQGKIAQ LEGKLVSIEK EKIDEKSETE KLLEYIEEIS CASDQVEKYK LDIAQLEENL KEKNDEILSL KQSLEENIVI LSKQVEDLNV KCQLLEKEKE DHVNRNREHN ENLNAEMQNL KQKFILEQQE REKLQQKELQ IDSLLQQEKE LSSSLHQKLC SFQEEMVKEK NLFEEELKQT LDELDKLQQK EEQAERLVKQ LEEEAKSRAE ELKLLEEKLK GKEAELEKSS AAHTQATLLL QEKYDSMVQS LEDVTAQFES YKALTASEIE DLKLELEHHH HHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 34.42 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 44 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant HMMR protein (His tag) SDS-PAGE
M: Marker; Lane 1: HMMR; Lane 2: BSA
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