Hexarelin peptide

Hexarelin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

1 Vial

His-(D-Mrp)-Ala-Trp- (D-Phe)-Lys-NH2

5

96.5%

Synthetic

Hexarelin (Hex) is a synthetic small peptide growth hormone-releasing peptide analog, a modified derivative of GHRP-6 with beneficial effects on lipid metabolism via the CD36receptor, shows cardioprotective effects both in vivo and in vitro (via GHS-R1a).It is chemically more stable and functionally more potent when compared with ghrelin, which has been shown to protect cardiomyocytes from ischemia-reperfusion processes.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Meanti R, Rizzi L, Bresciani E, Molteni L, Locatelli V, Coco S, Omeljaniuk RJ, Torsello A. Hexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide-Induced Apoptotic Toxicity. Pharmaceuticals (Basel). 2021 May 8;14(5):444. doi: 10.3390/ph14050444. PMID: 34066741; PMCID: PMC8150489.

Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

TFA Removal Service is recommended for:

• Peptides that will be used in cellular assays
• Peptides that will be used as APIs or in manufactured products
• For hydrophilic peptides containing numerous basic residues