Hexarelin peptide

Hexarelin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-d(2-Me)W-A-W-f-K-NH₂

H-His-D-Trp(2-Me)-Ala-Trp-D-Phe-Lys-NH2

5

96.5%

C₄₇H₅₈N₁₂O₆

877.05

Synthetic

Powder

Hexarelin (Hex) is a synthetic small peptide growth hormone-releasing peptide analog, a modified derivative of GHRP-6 with beneficial effects on lipid metabolism via the CD36receptor, shows cardioprotective effects both in vivo and in vitro (via GHS-R1a).It is chemically more stable and functionally more potent when compared with ghrelin, which has been shown to protect cardiomyocytes from ischemia-reperfusion processes.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Meanti R, Rizzi L, Bresciani E, Molteni L, Locatelli V, Coco S, Omeljaniuk RJ, Torsello A. Hexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide-Induced Apoptotic Toxicity. Pharmaceuticals (Basel). 2021 May 8;14(5):444. doi: 10.3390/ph14050444. PMID: 34066741; PMCID: PMC8150489.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.