Recombinant GRIK3 protein (His tag)

• DataSheet
• COA (Batch NP456384)
• Material Safety Data Sheets (MSDS)

This recombinant protein product features a 163-amino acid fragment (residues 658-820) of human Glutamate receptor ionotropic, kainate 3 (GluK3), a key ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel. The fragment has been computationally selected for optimal stability and solubility, making it ideal for structural studies and biochemical characterization of this important neuronal receptor.

Glutamate receptor ionotropic, kainate 3 (GluK3) is an excitatory neurotransmitter receptor that functions as a cation-permeable ligand-gated ion channel, activated by L-glutamate and the glutamatergic agonist kainic acid. Upon binding L-glutamate, the receptor undergoes conformational changes that open the cation channel, converting chemical signals to electrical impulses in neuronal communication. The receptor rapidly desensitizes and enters a transient inactive state after activation. In association with GRIK2, GluK3 participates in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses. The full-length protein is localized to the cell membrane and postsynaptic cell membrane as a multi-pass membrane protein, playing crucial roles in excitatory neurotransmission in the central nervous system.

MAAFLTVERM ESPIDSADDL AKQTKIEYGA VKDGATMTFF KKSKISTFEK MWAFMSSKPS ALVKNNEEGI QRALTADYAL
LMESTTIEYV TQRNCNLTQI GGLIDSKGYG IGTPMGSPYR DKITIAILQL QEEDKLHIMK EKWWRGSGCP EEENKEASAL
GIQKLEHHHH HH