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Product Name
Recombinant FCRL4 protein (His tag)
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Description
Recombinant Fc receptor-like protein 4 (FcRL4) fragment (amino acids 20-387) is a high-purity protein designed for studying B-cell receptor signaling and immune response mechanisms. This 368-amino acid fragment includes all four Ig-like C2-type domains, making it an ideal tool for domain-specific functional assays and immunological research.
Fc receptor-like protein 4 (FcRL4) functions as an inhibitor of B-cell receptor signaling and plays a role in B-cell-mediated immune responses. The protein is localized to the cell membrane as a single-pass type I membrane protein, positioning it to interact with extracellular signaling components while maintaining intracellular connectivity. This strategic localization enables FcRL4 to modulate B-cell activation pathways, making it a significant target for understanding immune regulation and potential therapeutic interventions in immune-related disorders.
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Protein name
Fc receptor-like protein 4
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Uniprot ID
Q96PJ5
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Gene Name
FCRL4; FCRH4; IFGP2; IRTA1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 20-387 aa (Q96PJ5) were fused with C-terminal 6His tag.
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Sequence
MNHKVAHKPV ISVHPPWTTF FKGERVTLTC NGFQFYATEK TTWYHRHYWG EKLTLTPGNT LEVRESGLYR CQARGSPRSN PVRLLFSSDS LILQAPYSVF EGDTLVLRCH RRRKEKLTAV KYTWNGNILS ISNKSWDLLI PQASSNNNGN YRCIGYGDEN DVFRSNFKII KIQELFPHPE LKATDSQPTE GNSVNLSCET QLPPERSDTP LHFNFFRDGE VILSDWSTYP ELQLPTVWRE NSGSYWCGAE TVRGNIHKHS PSLQIHVQRI PVSGVLLETQ PSGGQAVEGE MLVLVCSVAE GTGDTTFSWH REDMQESLGR KTQRSLRAEL ELPAIRQSHA GGYYCTADNS YGPVQSMVLN VTVRETPGNR DGLLEHHHHH H
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 43.26 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 43 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant FCRL4 protein (His tag) SDS-PAGE
M: Marker; Lane 1: FCRL4; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"