Recombinant BCL6 protein (His tag)

• DataSheet
• COA (Batch NP456520)
• Material Safety Data Sheets (MSDS)

Recombinant Human B-cell lymphoma 6 protein (BCL-6) fragment (amino acids 1-128) is a high-purity protein designed for studying the BTB domain's role in transcriptional repression and germinal center formation. This fragment serves as an essential tool for investigating domain-specific interactions and regulatory mechanisms in immunology and cancer research.

BCL-6 is a transcriptional repressor critical for germinal center formation, antibody affinity maturation, and immunological memory establishment. It functions by forming complexes with corepressors and histone deacetylases to repress genes involved in differentiation, inflammation, and cell cycle control, while enabling B-cell proliferation and tolerance to DNA damage during immune responses. The protein also regulates T-cell differentiation and neurogenesis via epigenetic mechanisms. BCL-6 localizes to the nucleus, where it directly binds DNA or modulates transcription factor activity. The provided fragment encompasses the BTB domain, enabling focused studies on its contribution to BCL-6's repressive functions and molecular interactions.

MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI FTDQLKCNLS VINLDPEINP
EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT CRKFIKASLE HHHHHH