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Product Name
Recombinant ZZZ3 protein (His tag)
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Description
Recombinant ZZ-type zinc finger-containing protein 3 (ZZZ3) fragment (residues 786-903), derived from Homo sapiens, offers a stable and soluble unit for investigating histone H3 recognition and its role in gene activation mechanisms. This 118-amino acid fragment is ideal for structural and biochemical studies, enabling researchers to explore epigenetic regulation with high reliability.
The full-length ZZZ3 protein functions as a histone H3 reader essential for the ATAC complex-mediated maintenance of histone acetylation and gene activation. As a component of the ATAC complex, it contributes to histone acetyltransferase activity targeting histones H3 and H4, playing a critical role in chromatin remodeling and transcriptional regulation. Located in the nucleus, ZZZ3 is pivotal in epigenetic processes, influencing cellular gene expression profiles. The selected fragment (786-903) was computationally designed to provide a stable, soluble representation for detailed analysis, supporting advancements in understanding epigenetic controls.
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Protein name
ZZ-type zinc finger-containing protein 3
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Uniprot ID
Q8IYH5
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Gene Name
ZZZ3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 786-903 aa (Q8IYH5) were fused with C-terminal 6His tag.
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Sequence
MSKIKYRNLP EYKELLQFKK LKKQKLQQMQ AESGFVQHVG FKCDNCGIEP IQGVRWHCQD CPPEMSLDFC DSCSDCLHET DIHKEDHQLE PIYRSETFLD RDYCVSQGTS YNYLDPNYFP ANRLEHHHHH H
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 15.61 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 17 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant ZZZ3 protein (His tag) SDS-PAGE
M: Marker; Lane 1: ZZZ3; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"