-
Product Name
Recombinant ZNT8 protein (His tag)
- Documents
-
Description
Recombinant Human SLC30A8 Fragment (267-369) - A high-quality recombinant protein representing a stable and soluble fragment of the proton-coupled zinc antiporter SLC30A8 (ZnT-8), specifically engineered for structural and biochemical research applications.
SLC30A8 (Zinc transporter 8) is a proton-coupled zinc ion antiporter that mediates zinc entry into the lumen of pancreatic beta cell secretory granules, playing a critical role in regulating insulin secretion. The full-length protein localizes to cytoplasmic vesicle and secretory vesicle membranes, as well as the cell membrane, where it functions as a multi-pass membrane protein associated with insulin and glucagon secretory granules. This transporter is essential for maintaining zinc homeostasis in pancreatic beta cells, making it a protein of significant interest in diabetes research and metabolic studies.
-
Protein name
Proton-coupled zinc antiporter SLC30A8
-
Uniprot ID
Q8IWU4
-
Gene Name
SLC30A8; ZNT8
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 267-369 aa (Q8IWU4) were fused with N-terminal 6His tag.
-
Sequence
MNHKVHHHHH HGGSLKDFSI LLMEGVPKSL NYSGVKELIL AVDGVLSVHS LHIWSLTMNQ VILSAHVATA ASRDSQVVRR EIAKALSKSF TMHSLTIQME SPVDQDPDCL FCEDPCD
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 12.96 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
-
Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
-
Validations
Recombinant ZNT8 protein (His tag) SDS-PAGE
M: Marker; Lane 1: ZNT8; Lane 2: BSA
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"