Ziptide peptide

Ziptide peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-KKLNRTLSFAEPG-OH

H-Lys-Lys-Leu-Asn-Arg-Thr-Leu-Ser-Phe-Ala-Glu-Pro-Gly-OH

13

95.33%

C₆₅H₁₀₉N₁₉O₁₉

1460.67

Synthetic

Powder

Ziptide is a substrate peptide used routinely as a substrate for zipper interacting protein kinase (ZIPK), also known as death-associated protein kinase 3 (DAPK3), a serine/threonine kinase that functions in programmed cell death. Ziptide can also be used as a substrate for the other serine/threonine-protein kinases BRSK2, and maternal embryonic leucine zipper kinase (MELK).

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Witczak et al (2010) CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 298(6) E1150 PMID: 20215576
• Yoshida and Goedert (2012) Phosphorylation of microtubule-associated protein tau by AMPK-related kinases. J. Neurochem. 120 165 PMID: 21985311

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.