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Product Name
Recombinant ZBT49 protein (His tag)
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Description
Recombinant Human ZBTB49 (Zinc finger and BTB domain-containing protein 49) Fragment (1-119) is a high-purity protein designed for functional studies. This fragment fully encompasses the BTB domain, making it an ideal tool for investigating domain-specific interactions and regulatory mechanisms in transcription and cell proliferation pathways.
ZBTB49 is a transcription factor that inhibits cell proliferation by activating CDKN1A/p21 or RB1 transcription. Isoform 1 binds the CDKN1A promoter and synergistically enhances transcription with EP300, while Isoform 3 activates RB1 transcription by antagonizing ZBTB17 repression. The protein localizes to both the cytoplasm and nucleus, with predominant nuclear presence, underscoring its role in gene regulation and cell cycle control.
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Protein name
Zinc finger and BTB domain-containing protein 49
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Uniprot ID
Q6ZSB9
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Gene Name
ZBTB49; ZNF509
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-119 aa (Q6ZSB9) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 15.15 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"