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Product Name
Recombinant ZBT21 protein (His tag)
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Description
Recombinant Human ZBTB21 (1-119) fragment is a high-purity protein product encompassing the BTB domain of Zinc finger and BTB domain-containing protein 21. This fragment serves as an essential tool for investigating the domain-specific transcriptional repressor functions of ZBTB21 in cellular regulation.
Zinc finger and BTB domain-containing protein 21 (ZBTB21), encoded by the gene ZBTB21, functions as a transcription repressor, playing a key role in modulating gene expression. It is localized to the nucleus, where it colocalizes with ZBTB14 in HEK293 cells, indicating its involvement in nuclear regulatory complexes. The BTB domain, contained within this recombinant fragment (amino acids 30-96), is critical for protein-protein interactions and repression activity, making this product valuable for studying the mechanistic basis of ZBTB21-mediated transcriptional control.
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Protein name
Zinc finger and BTB domain-containing protein 21
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Uniprot ID
Q9ULJ3
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Gene Name
ZBTB21; KIAA1227; ZNF295
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-119 aa (Q9ULJ3) were fused with C-terminal 6His tag.
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Sequence
MEGLLHYINP AHAISLLSAL NEERLKGQLC DVLLIVGDQK FRAHKNVLAA SSEYFQSLFT NKENESQTVF QLDFCEPDAF DNVLNYIYSS SLFVEKSSLA AVQELGYSLG ISFLTNIVSL EHHHHHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 14.33 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 12 kDa band. (High content of acidic amino acids accelerates protein migration in SDS-PAGE, leading to lower apparent molecular weight.)
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Purity
>95%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant ZBT21 protein (His tag) SDS-PAGE
M: Marker; Lane 1: ZBT21; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"