Cart 2
  • Y-2, a CTLA-4/B7 inhibition peptide

Y-2, a CTLA-4/B7 inhibition peptide

Not For Human Use, Lab Use Only.

Cat.#: 318753

Size:

* Buy 1 get 1 free (?)

Special Price 408.00 USD

Availability: 5 working days
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Y-2, a CTLA-4/B7 inhibition peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    Ac-c(CAWGLAILEGELAWLEGGGGGGGQLADLKRQLAWLKQAC)-NH2
  • Sequence
    AC-Cyclo(Cys-Ala-Trp-Gly-Leu-Ala-Ile-Leu-Glu-Gly-Glu-Leu-Ala-Trp-Leu-Glu-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gln-Leu-Ala-Asp-Leu-Lys-Arg-Gln-Leu-Ala-Trp-Leu-Lys-Gln-Ala-Cys)-NH2
  • Length (aa)
    39
  • Peptide Purity (HPLC)
    95.2%
  • Molecular Formula
    C183H285N51O51S2
  • Molecular Weight
    4079.66
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Y2 is a helix-loop-helix (HLH) peptide, which is an alternative option for the inhibition of specific protein interactions. Cytotoxic T lymphocyte antigen-4 (CTLA4) downregulates immune responses of cytotoxic T-cells by interaction with B7-1, a co-stimulatory molecule expressed on antigen presenting cells (APCs). Y2 may potentially binds to CTLA4, inhibiting the CTLA-4/B7-1 interaction and inducing immune stimulatory activity.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References

    • Ramanayake Mudiyanselage TMR, Michigami M, Ye Z, et al. An Immune-Stimulatory Helix-Loop-Helix Peptide: Selective Inhibition of CTLA-4-B7 Interaction [published online ahead of print, 2020 Jan 8].u00a0ACS Chem Biol. 2020;10.1021/acschembio.9b00743. doi:10.1021/acschembio.9b00743

  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight

Peptide Property

  • Analysed Sequence:A
  • Chemical Formula:A
  • Sequence length:A
  • Extinction coefficient:A M-1cm-1
  • GRAVY:A
  • Mw average:A
  • Theoretical pI:A
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"