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  • XT-2 peptide

XT-2 peptide

Not For Human Use, Lab Use Only.

Cat.#: 311681

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Product Information

  • Product Name
    XT-2 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    GCWSTVLGGLKKFAKGGLEAIVNPK
  • Sequence
    Gly-Cys-Trp-Ser-Thr-Val-Leu-Gly-Gly-Leu-Lys-Lys-Phe-Ala-Lys-Gly-Gly-Leu-Glu-Ala-Ile-Val-Asn-Pro-Lys
  • Length (aa)
    25
  • Peptide Purity (HPLC)
    95.9%
  • Molecular Formula
    C118H193N31O31S
  • Molecular Weight
    2574.05
  • CAS No.
    1235883-67-6
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The XT-2 peptide is an antimicrobial peptide isolated from norepinephrine-stimulated skin secretions of the diploid clawed frog Xenopus tropicalis. It is one of seven peptides (XT-1 to XT-7) characterized from these secretions. Structural analysis indicates that XT-2 shows similarity to the spacer region of proxenopsin from Xenopus laevis, and it is considered a potential ortholog. The peptide XT-2, along with its paralog XT-4, was eluted in a chromatographic fraction that exhibited growth-inhibitory activity specifically against Escherichia coli in antimicrobial assays.

    The primary structure of XT-2 was determined by Edman degradation and confirmed by mass spectrometry. Among the isolated peptides, XT-2 demonstrated a selective antimicrobial profile, showing activity against E. coli but not against Staphylococcus aureus under the tested conditions. This peptide contributes to the diverse array of antimicrobial peptides found in X. tropicalis skin secretions, which exhibit varied structural features and biological activities.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Ali MF, Soto A, Knoop FC, Conlon JM. Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae). Biochim Biophys Acta. 2001;1550(1):81-9.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"