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  • WL47 peptide

WL47 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319775

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* Buy 1 get 1 free (?) What is TFA?

Special Price 128.40 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    WL47 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-KLRMWSCCSWMRLK-OH
  • Sequence
    H-Lys-Leu-Arg-Met-Trp-Ser-Cys-Cys-Ser-Trp-Met-Arg-Leu-Lys-OH
  • Length (aa)
    14
  • Peptide Purity (HPLC)
    95.91%
  • Molecular Formula
    C80H130N24O17S4
  • Molecular Weight
    1828.29
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The peptide WL47 is a small, high-affinity ligand designed to selectively disrupt caveolin-1 (CAV) oligomers. Derived from the T20 parent sequence, WL47 exhibits a 7500-fold improvement in binding affinity while being 80% shorter in length. Its development involved iterative screening and optimization of synthetic peptide libraries, focusing on key residues essential for CAV interaction. WL47 demonstrates specificity for CAV and functions as a dimer, with positive cooperativity observed in its binding mechanism. This peptide serves as a valuable molecular tool for studying CAV's structural and functional properties.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Gilliam AJ, Smith JN, Flather D, Johnston KM, Gansmiller AM, Fishman DA, Edgar JM, Balk M, Majumdar S, Weiss GA. Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization. J Med Chem. 2016 Apr 28;59(8):4019-25. doi: 10.1021/acs.jmedchem.5b01536. Epub 2016 Apr 11. PMID: 27010220; PMCID: PMC5529100.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"