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Product Name
Recombinant WDR5B protein (His tag)
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Description
This product is a high-quality recombinant fragment of human WD repeat-containing protein 5B (WDR5B), encompassing residues 1-330. This fragment was computationally designed for optimal stability and solubility, making it an ideal reagent for structural biology studies and biochemical characterization of this potential substrate receptor for the CUL4-DDB1 ubiquitin ligase complex.
The full-length WD repeat-containing protein 5B (WDR5B), encoded by the gene WDR5B, is implicated in the ubiquitin-proteasome system. Based on the provided functional annotation, it may act as a substrate receptor component within the CUL4-DDB1 E3 ubiquitin ligase complex. Such complexes are crucial for targeting specific proteins for degradation, a fundamental process regulating numerous cellular pathways including DNA repair, cell cycle progression, and signal transduction. The study of WDR5B's function is therefore significant for understanding protein homeostasis and related biological mechanisms.
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Protein name
WD repeat-containing protein 5B
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Uniprot ID
Q86VZ2
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Gene Name
WDR5B
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-330 aa (Q86VZ2) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 37.99 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 38 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"