W379 peptide

W379 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-RRRWWWWV-OH

H-Arg-Arg-Arg-Trp-Trp-Trp-Trp-Val-OH

8

99.22%

C₆₇H₈₇N₂₁O₉

1330.55

Synthetic

Powder

W379 is a LL-37 mimetic peptide. Compared to LL-37 (37 residues), W379 comprises only eight amino acids (sequence: RRRWWWWV). W379 maintains a broad-spectrum antimicrobial activity and simultaneously exhibits superiority in several aspects, including a unique amphipathic structure and a significant reduction in production cost. W379 peptide can enhance skin cell migration in an in vitro wound-healing assay. In vivo studies indicated patterned macrochannels in nanofiber aerogels can greatly enhance vascularized granulation tissue formation and the addition of W379 can promote not only vascularized granulation tissue formation but also re-epithelialization. The enhanced wound healing by W379 could be due to the activation of the p38 MAPK signaling pathway.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• John JV, Sharma NS, Tang G, Luo Z, Su Y, Weihs S, Shahriar SMS, Wang G, McCarthy A, Dyke J, Zhang YS, Khademhosseini A, Xie J. Nanofiber Aerogels with Precision Macrochannels and LL-37-Mimic Peptides Synergistically Promote Diabetic Wound Healing. Adv Funct Mater. 2023 Jan 3;33(1):2206936. doi: 10.1002/adfm.202206936. Epub 2022 Oct 31. PMID: 36714167; PMCID: PMC9881731.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.