VPV peptide

VPV peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-VPV-OH

H-Val-Pro-Val-OH

3

95.46%

C₁₅H₂₇N₃O₄

313.39

Synthetic

Powder

VPV is a DPP-IV(Dipeptidyl peptidase IV) inhibitory peptide. VPV 450 had a DPP-IV IC50 value of 6.6-0.5 µM. VPV originates from camel beta-CN (f213-215). VPV was reported during the generation of a bovine CN hydrolysate as a potent DPP-IV inhibitor having an IC50 value of 3.19 µM (Yamada, Sakurai & Ochi, 2017). VPV can also be found within other mammalian beta-CNs, including those originating from donkey, chimpanzee, pig and human. VPV is the second most potent DPP-IV inhibitory peptide found in food hydrolysates.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Nongonierma AB, Cadamuro C, Le Gouic A, Mudgil P, Maqsood S, FitzGerald RJ. Dipeptidyl peptidase IV (DPP-IV) inhibitory properties of a camel whey protein enriched hydrolysate preparation. Food Chem. 2019

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.