Recombinant VPS28 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human VPS28 protein fragment (residues 1-221) offers a high-purity tool for investigating the ESCRT-I complex's role in vesicular trafficking. This fragment encompasses the full-length VPS28 sequence, including its critical N-terminal and C-terminal domains, making it ideal for functional studies, protein-protein interaction assays, and mechanistic research on endosomal sorting.

Vacuolar protein sorting-associated protein 28 homolog (VPS28) is a key component of the ESCRT-I complex, which regulates essential vesicular trafficking processes, including endosomal sorting and membrane remodeling. Located at the cell membrane and late endosome membrane as a peripheral membrane protein, VPS28 contributes to the complex's ability to mediate protein sorting and degradation pathways. The ESCRT-I complex, through subunits like VPS28, ensures proper cellular homeostasis by directing ubiquitinated cargo to lysosomal degradation, playing a critical role in cellular physiology and disease mechanisms.