VnP-16 peptide

VnP-16 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-RVYFFKGKQYWE-NH2

H-Arg-Val-Tyr-Phe-Phe-Lys-Gly-Lys-Gln-Tyr-Trp-Glu-NH2

12

95.57%

C₈₂H₁₁₂N₂₀O₁₇

1649.88

Synthetic

Powder

VnP-16 is a peptide corresponding to residues 270–281 of human vitronectin, which exerts an anti-osteoporotic effect via β1 and αvβ3 integrin signaling. VnP-16 promotes bone formation by accelerating osteoblast differentiation through direct interaction with β1 integrin followed by FAK activation, while inhibiting bone resorption through restraint of JNK-c-Fos-NFATc1 induced osteoclast differentiation and αvβ3 integrin-c-Src-PYK2 mediated resorption. In a mouse model of estrogen deficiency induced osteoporosis, VnP-16 reverses ovariectomy induced bone loss by increasing osteoblast differentiation and promoting bone formation, while decreasing osteoclastogenesis and inhibiting bone resorption.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Min et al (2018) A vitronectin-derived peptide reverses ovariectomy-induced bone loss via regulation of osteoblast and osteoclast differentiation. Cell Death Differ. 25(2) 268 PMID: 28937683
• Min et al (2022) Vitronectin-derived bioactive peptide prevents spondyloarthritis by modulating Th17/Treg imbalance in mice with curdlan-induced spondyloarthritis. PLoS One 17(1) e0262183 PMID: 34986165
• Kang et al (2022) A Vitronectin-Derived Peptide Restores Ovariectomy-Induced Bone Loss by Dual Regulation of Bone Remodeling. Tissue Eng Regen Med. Oct 7 doi: 10.1007/s13770-022-00486-w. Epub ahead of print. PMID: 36207661

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.