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Recombinant VHLL protein (His tag)

Recombinant VHLL protein (His tag)

Cat.#: 549527

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Product Information

  • Product Name
    Recombinant VHLL protein (His tag)
  • Documents
  • Description

    Recombinant Human von Hippel-Lindau-like protein (VHL-like protein, VLP) fragment (residues 43-139) is a high-purity, stable protein designed for structural and biochemical studies. This 97-amino acid fragment mimics dominant-negative VHL activity, serving as a key tool to investigate HIFalpha stabilization pathways.

    The full-length von Hippel-Lindau-like protein (VHL-like protein, VLP) functions as a dominant-negative regulator of VHL, acting as a protector of HIFalpha proteins. This mechanism is significant in oxygen-sensing pathways, where VLP's interference with VHL-mediated degradation of HIFalpha may influence hypoxic response regulation. The described recombinant fragment represents a soluble, stable unit optimized for experimental applications.

  • Protein name
    von Hippel-Lindau-like protein
  • Uniprot ID
    Q6RSH7
  • Gene Name
    VHLL; VLP
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 43-139 aa (Q6RSH7) were fused with 6His tag.
  • Sequence 
    43-139
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 12.96 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 13 kDa band.
  • Purity
    >86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"