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Product Name
Recombinant VEGFD protein (His tag)
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Description
Recombinant Human VEGF-D (Vascular Endothelial Growth Factor D) Fragment (aa 89-205) is a high-purity protein designed for structural and biochemical studies. This 117-amino acid fragment represents a stable and soluble domain of VEGF-D, a key regulator of angiogenesis and lymphangiogenesis, making it ideal for investigating endothelial cell signaling and vascular biology.
Vascular Endothelial Growth Factor D (VEGF-D), also known as c-Fos-induced growth factor (FIGF), is a secreted growth factor that plays critical roles in angiogenesis, lymphangiogenesis, and endothelial cell proliferation and migration. It enhances blood vessel permeability and is essential for the development of venous and lymphatic vascular systems during embryogenesis, as well as for maintaining differentiated lymphatic endothelium in adults. VEGF-D exerts its biological effects by binding and activating VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors, positioning it as a significant target for research in vascular biology and related therapeutic applications.
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Protein name
Vascular endothelial growth factor D
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Uniprot ID
O43915
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Gene Name
VEGFD; FIGF
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 89-205 aa (O43915) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 14.76 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"