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  • Urocortin 1 peptide

Urocortin 1 peptide

Not For Human Use, Lab Use Only.

Cat.#: 312516

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Urocortin 1 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    EDPPISIDLTFHILRQMIEIAKTQNQKQQAEQNRIIFDSV
  • Sequence
    Glu-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Ile-Leu-Arg-Gln-Met-Ile-Glu-Ile-Ala-Lys-Thr-Gln-Asn-Gln-Lys-Gln-Gln-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val
  • Length (aa)
    40
  • Peptide Purity (HPLC)
    95.23%
  • Molecular Formula
    C207H336N58O65S
  • Molecular Weight
    4709.35
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Urocortin 1 is a neuropeptide belonging to the corticotropin-releasing factor (CRF) family. It is a 40-amino acid peptide that shares high sequence similarity with fish urotensin I and mammalian urocortin 1. In vertebrates, urocortin 1 binds to and activates both CRF1 and CRF2 receptors, typically exhibiting higher affinity for the CRF2 receptor subtype. This peptide is expressed in multiple tissues including the brain, pituitary, heart, and kidney.

    Phylogenetic analyses indicate that the urocortin 1 gene lineage arose before the divergence of bony fishes and tetrapods, demonstrating deep evolutionary conservation. The peptide's functional interactions with CRF receptors and its tissue distribution pattern are conserved across vertebrate species, highlighting its fundamental role in neuroendocrine signaling pathways.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Boorse GC, Crespi EJ, Dautzenberg FM, Denver RJ. Urocortins of the South African clawed frog, Xenopus laevis: conservation of structure and function in tetrapod evolution. Endocrinology. 2005;146(11):4851-60.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"