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Product Name
Recombinant ULBP1 protein (His tag)
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Description
Recombinant UL16-binding protein 1 (ULBP1) fragment (residues 26-216), a stable and soluble unit of this key human NKG2D ligand, designed for high-quality structural and functional studies in immunology and cancer research.
ULBP1, also known as ALCAN-beta or NKG2D ligand 1, is a human protein that binds and activates the KLRK1/NKG2D receptor, playing a critical role in mediating natural killer cell cytotoxicity. This immune recognition function makes it significant in immune surveillance against infected or transformed cells. The protein is primarily localized to the cell membrane via a GPI-anchor, though it has also been detected in the endoplasmic reticulum/cis-Golgi compartment, particularly in CMV-infected cells, suggesting complex regulatory trafficking. The recombinant fragment (26-216) encompasses the core functional domain, providing a valuable tool for investigating NKG2D-mediated immune responses.
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Protein name
UL16-binding protein 1
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Uniprot ID
Q9BZM6
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Gene Name
ULBP1; N2DL1; RAET1I
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 26-216 aa (Q9BZM6) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 23.98 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 25 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"