-
Product Name
Recombinant TVA21 protein (His tag)
- Documents
-
Description
Recombinant T cell receptor alpha variable 21 (TRAV21) fragment (residues 20-112) from Homo sapiens, engineered for structural and functional studies. This 93-amino acid soluble fragment represents a stable, antigen-recognizing variable domain, ideal for investigating T cell receptor biology and immune response mechanisms.
The T cell receptor alpha variable 21 (TRAV21) is a crucial component of the alpha-beta T cell receptor complex, which mediates antigen-specific immune responses. As part of the variable domain, TRAV21 directly participates in recognizing peptide-major histocompatibility (pMH) complexes displayed by antigen-presenting cells. This recognition initiates T cell activation through intracellular signaling cascades involving CD3 complex phosphorylation, ZAP70 recruitment, and downstream calcium, MAPK, and NF-kB pathways, ultimately driving T cell proliferation and differentiation. The receptor is membrane-bound and undergoes V-(D)-J rearrangement during thymic development to generate a d
-
Protein name
T cell receptor alpha variable 21
-
Uniprot ID
A0A0B4J279
-
Gene Name
TRAV21
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 20-112 aa (A0A0B4J279) were fused with C-terminal 6His tag.
-
Sequence
MSKIKKQEVT QIPAALSVPE GENLVLNCSF TDSAIYNLQW FRQDPGKGLT SLLLIQSSQR EQTSGRLNAS LDKSSGRSTL YIAASQPGDS ATYLCAVRLE HHHHHH
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 11.70 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 12 kDa band.
-
Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
-
Validations
Recombinant TVA21 protein (His tag) SDS-PAGE
M: Marker; Lane 1: TVA21; Lane 2: BSA
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"