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  • TRV056 peptide

TRV056 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319797

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* Buy 1 get 1 free (?) What is TFA?

Special Price 101.70 USD

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Product Information

  • Product Name
    TRV056 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-DRGVYIHPF-OH
  • Sequence
    H-Asp-Arg-Gly-Val-Tyr-Ile-His-Pro-Phe-OH
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.23%
  • Molecular Formula
    C52H74N14O13
  • Molecular Weight
    1103.22
  • CAS No.
    812644-79-4
  • PubChem CID
    11205505
  • Source
    Synthetic
  • Form
    Powder
  • Description

    TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), a G protein-coupled receptor (GPCR). Compared to the endogenous agonist angiotensin II (AngII), TRV056 exhibits enhanced Gq coupling and cellular signaling while maintaining similar efficacy towards β-arrestin. Structural studies using double electron-electron resonance (DEER) spectroscopy reveal that TRV056 stabilizes distinct receptor conformations characterized by an outward displacement of transmembrane helix 6 (TM6) and specific rearrangements in intracellular loop 2 (ICL2) and helix 8 (H8). These conformational changes are associated with an accessible transducer-binding site, rationalizing TRV056's enhanced Gq activity. The peptide's C-terminal modifications, particularly at position 8, play a critical role in determining its biased signaling profile by influencing receptor dynamics and transducer coupling.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11. doi: 10.1016/j.cell.2018.12.005. Epub 2019 Jan 10. PMID: 30639099; PMCID: PMC6475118.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"