Trichoplaxin (unclassified simpliest animals) peptide

Trichoplaxin (unclassified simpliest animals) peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

FFGRLKSVWSAVKHGWKAAKSR

Phe-Phe-Gly-Arg-Leu-Lys-Ser-Val-Trp-Ser-Ala-Val-Lys-His-Gly-Trp-Lys-Ala-Ala-Lys-Ser-Arg

22

95.3%

Synthetic

Powder

41.6% similar to Phylloseptin-H9 and NRC-10. The peptide was identified from Trichoplax adhaerens, the only described species in the phylum Placozoa, structurally simplest multicellular animal. Active against Gram+ S. aureus (MRSA), L. ivanovii (MIC 3 uM), E. faecalis (MIC 12.5 uM), Gram- bacteria E. coli ATCC 25922, P. aeruginosa ATCC 27853, A. baumannii ATCC 19606, K. pneumoniae ATCC 13883 (MIC 3-6 uM), fungi C. albicans ATCC 90028 and C. parapsilosis ATCC 22019 (MIC 25-50 uM). This peptide showed a relatively good cell selectivity index (65-260). Trichoplaxin is random in water but helical in the presence of membrane-mimetic models such as SDS or TFE. Reg. 9/29/2014; 12/16/2014. Trichoplaxin (unclassified simpliest animals) was found in identified in the EST database, Trichoplax adhaerens.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Simunić J, Petrov D, Bouceba T, Kamech N, Benincasa M, Juretić D. Trichoplaxin - a new membrane-active antimicrobial peptide from placozoan cDNA. Biochim Biophys Acta. 2014;1838(5):1430-8.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.