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Product Name
Recombinant TRIB2 protein (His tag)
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Description
Our recombinant Human Tribbles homolog 2 (TRB-2) fragment (amino acids 59-313) provides researchers with a high-quality tool specifically designed to study the protein kinase domain of this important MAP kinase regulator. This 255-amino acid fragment fully encompasses the functional kinase domain, making it ideal for investigating TRB-2's role in cellular signaling pathways.
Tribbles homolog 2 (TRB-2), encoded by the TRIB2 gene, functions as a key regulator of MAP kinase signaling pathways. The protein interacts with MAPK kinases and modulates the activation of MAP kinases, though it lacks intrinsic kinase activity itself. TRB-2 is primarily localized in the cytoplasm, with potential association to the cytoskeleton, suggesting its involvement in spatially regulated signaling complexes. This strategic localization positions TRB-2 as a critical modulator of intracellular signaling cascades that control various cellular processes.
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Protein name
Tribbles homolog 2
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Uniprot ID
Q92519
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Gene Name
TRIB2; TRB2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 59-313 aa (Q92519) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 30.73 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 32 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"