Recombinant TRIB1 protein (His tag)

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Recombinant Human Tribbles homolog 1 (TRB-1) Fragment (aa 89-372) is a high-purity protein designed for studying the protein kinase domain. This fragment serves as an essential tool for investigating TRB-1's role as an adapter protein in ubiquitin-mediated degradation and MAPK signaling pathways, providing researchers with a focused reagent for domain-specific functional assays.

Tribbles homolog 1 (TRB-1), encoded by the TRIB1 gene, functions as an adapter protein that interacts with the COP1 ubiquitin ligase to regulate protein degradation, particularly targeting CEBPA. This interaction alters COP1 substrate specificity and plays a critical role in myeloid cell differentiation, including macrophage, eosinophil, and neutrophil development. TRB-1 also binds MAPK kinases and modulates MAP kinase activation pathways, despite lacking intrinsic kinase activity itself. The protein's COP1-binding motif is regulated through autoinhibitory interactions with its protein kinase domain, making the study of this domain crucial for understanding TRB-1's regulatory mechanisms in cellular signaling and differentiation processes.