Transportan peptide

Transportan peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-GWTLNSAGYLLGKINLKALAALAKKIL-OH

H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Lys-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-OH

27

95.22%

C₁₃₄H₂₂₆N₃₄O₃₃

2841.42

Synthetic

Powder

Transportan is a 27 amino acid chimeric peptide consisting of 12 amino acids from the amino terminal of galanin and the 14 amino acid peptide mastoparan connected via a lysine residue. Transportan possesses characteristics of both galanin and mastoparan as it inhibits the binding of galanin to the GALR-1 receptor as well as modulating the activity of G proteins through inhibition of GTPase. Transportan is a cell-penetrating peptide which can penetrate into many cell types in a rapid and efficient way. In the cell interior, Transportan localizes mostly in membranous structures and is conveyed into the nuclei, where it concentrates in the nucleoli.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Pooga et al (1998) Cell penetration by transportan. FASEB J. 12(1) 67 PMID: 9438412
• Pooga et al (2001), Cellular translocation of proteins by transportan. FASEB J. 5 1451 PMID: 11387254
• Aguiar etal (2019) Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites. Med. Chem. Commun. 10 221 PMID: 30881610

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.