Recombinant TPR protein (His tag)

• DataSheet
• COA (Batch NP456417)
• Material Safety Data Sheets (MSDS)

Recombinant Human TPR Nucleoprotein Fragment (aa 2-358) is a highly stable and soluble protein fragment derived from the nuclear pore complex scaffolding protein, ideal for structural studies and biochemical assays investigating nucleocytoplasmic transport mechanisms.

The full-length TPR protein (also known as Megator or Translocated promoter region protein) serves as a critical structural component of the nuclear pore complex (NPC), functioning as a scaffolding element essential for nucleocytoplasmic transport of proteins and mRNAs. It plays multifaceted roles in nuclear organization, including establishment of chromatin compartmentalization, quality control of unspliced mRNAs, and regulation of spindle-assembly checkpoint signaling during mitosis. TPR localizes primarily to the nuclear basket of NPCs but demonstrates dynamic subcellular redistribution during cell division, associating with spindle apparatus and kinetochores. This 357-amino acid fragment represents a computationally optimized stable

MSKIKAAVLQ QVLERTELNK LPKSVQNKLE KFLADQQSEI DGLKGRHEKF KVESEQQYFE IEKRLSHSQE RLVNETRECQ
SLRLELEKLN NQLKALTEKN KELEIAQDRN IAIQSQFTRT KEELEAEKRD LIRTNERLSQ ELEYLTEDVK RLNEKLKESN
TTKGELQLKL DELQASDVSV KYREKRLEQE KELLHSQNTW LNTELKTKTD ELLALGREKG NEILELKCNL ENKKEEVSRL
EEQMNGLKTS NEHLQKHVED LLTKLKEAKE QQASMEEKFH NELNAHIKLS NLYKSAADDS EAKSNELTRA VEELHKLLKE
AGEANKAIQD HLLEVEQSKD QMEKEMLEKI GRLEKELENA NDLEHHHHHH