Recombinant TP4A3 protein (His tag)

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Recombinant Human Protein Tyrosine Phosphatase Type IVA 3 (PRL-3) Fragment (residues 1-170): A high-purity, functional fragment encompassing the complete tyrosine-protein phosphatase domain. This product is an essential tool for investigating cell proliferation, motility, and metastasis mechanisms, offering researchers a targeted reagent for domain-specific studies in cancer biology and signal transduction.

Protein Tyrosine Phosphatase Type IVA 3 (PRL-3), encoded by the PTP4A3 gene, is a key regulatory enzyme that promotes cell cycle progression from G1 to S phase, enhances cell proliferation, motility, and invasive activity, and drives cancer metastasis. It has also been implicated in modulating cardiac hypertrophy by suppressing intracellular calcium mobilization in response to angiotensin II. The protein localizes to the cell membrane and early endosomes, facilitating its role in signal transduction pathways. This recombinant fragment retains the functional phosphatase domain, enabling focused analysis of its enzymatic activity and contribution to cellular processes.