TMTP1 peptide

TMTP1 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-NVVRQC-OH

H-Asn-Val-Val-Arg-Gln-Cys-OH

6

95.46%

C₂₈H₅₁N₁₁O₉S

717.83

Synthetic

Powder

The TMTP1 polypeptide is the five amino acid sequence NVVRQ identified by using the bacterial flagellin library display technology. TMTP1 could target the primary highly metastatic tumor and the micrometastases. TMTP1 also specifically recognized atypical liver micrometastases that contained infrequent neoplastic cells. Binding peptides and fusion proteins prepared by combining TMTP1 with apoptotic peptides or diphtheria toxin could specifically inhibit tumor metastasis. XPNPEP2, a subtype of aminopeptidase P, is the potential receptor of TMTP1. XPNPEP2 expression was obviously upregulated in CC tissue and that overexpression of XPNPEP2 was correlated with lymph node metastasis and worse overall survival. TMTP1 polypeptide can be used to develop new diagnostic agents for the CC metastasis, especially micrometastasis.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Wei R, Jiang G, Lv M, Tan S, Wang X, Zhou Y, Cheng T, Gao X, Chen X, Wang W, Zou C, Li F, Ma X, Hu J, Ma D, Luo D, Xi L. TMTP1-modified Indocyanine Green-loaded Polymeric Micelles for Targeted Imaging of Cervical Cancer and Metastasis Sentinel Lymph Node in vivo. Theranostics. 2019 Sep 25;9(24):7325-7344. doi: 10.7150/thno.35346. PMID: 31695771; PMCID: PMC6831285.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.