Recombinant TMM9B protein (His tag)

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This recombinant protein product features a 71-amino acid fragment (residues 34-104) of human Transmembrane protein 9B (TMEM9B), specifically designed for structural and biochemical studies. The fragment represents a stable, soluble unit of this important immune regulatory protein, enabling researchers to investigate mechanisms of inflammatory signaling without the complications of full-length membrane protein expression.

Transmembrane protein 9B (TMEM9B) is a human protein that plays a crucial role in inflammatory signaling pathways. It enhances the production of pro-inflammatory cytokines induced by TNF, IL1B, and TLR ligands, and participates in TNF activation of both NF-kappaB and MAPK signaling pathways. The full-length protein localizes to lysosome and early endosome membranes as a single-pass membrane protein, positioning it strategically within cellular compartments involved in immune signaling and response regulation. This makes TMEM9B an important target for research into inflammatory diseases and immune system function.