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  • TLQP-21 peptide

TLQP-21 peptide

Not For Human Use, Lab Use Only.

Cat.#: 317601

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Product Information

  • Product Name
    TLQP-21 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    TLQPPASSRRRHFHHALPPAR
  • Sequence
    H-Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg-OH
  • Length (aa)
    21
  • Peptide Purity (HPLC)
    95.5%
  • Molecular Formula
    C107H171N41O25
  • Molecular Weight
    2431.33
  • CAS No.
    869988-94-3
  • Source
    Synthetic
  • Form
    Powder
  • Description

    TLQP-21 is a multifunctional peptide derived from the VGF propeptide. It is involved in the regulation of various physiological functions. In microglial cells, TLQP-21 stimulates an increase in intracellular calcium levels. This calcium elevation can subsequently activate calcium-dependent potassium outward currents, specifically involving channels such as KCa3.1.

    The peptide's C-terminal region is critical for its biological activity. Studies using analogues like JMV5656, which retains the C-terminal sequence, demonstrate that this fragment is sufficient to elicit intracellular calcium mobilization and the activation of potassium currents. The mechanism involves an interaction with cellular receptors, leading to calcium influx and the opening of calcium-activated potassium channels, which contributes to the modulation of membrane potential and calcium homeostasis in these cells.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Rivolta I, Binda A, Molteni L, Rizzi L, Bresciani E, Possenti R, Fehrentz JA, Verdié P, Martinez J, Omeljaniuk RJ, Locatelli V, Torsello A. JMV5656, A Novel Derivative of TLQP-21, Triggers the Activation of a Calcium-Dependent Potassium Outward Current in Microglial Cells. Front Cell Neurosci. 2017 Feb 23;11:41. doi: 10.3389/fncel.2017.00041. PMID: 28280458; PMCID: PMC5322282.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"