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Product Name
Recombinant TIM22 protein (His tag)
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Description
This product is a recombinant fragment of the Mitochondrial import inner membrane translocase subunit Tim22 (Testis-expressed protein 4), corresponding to amino acids 1-73. It is designed for structural and biochemical studies, offering a stable and soluble unit ideal for investigating the protein's role in mitochondrial membrane protein import.
The full-length TIMM22 protein is an essential core component of the TIM22 complex, which mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. It functions as the voltage-activated and signal-gated channel within this complex, utilizing the membrane potential as an external driving force in two voltage-dependent steps. Located in the mitochondrial inner membrane as a multi-pass membrane protein, TIMM22 plays a critical role in maintaining mitochondrial function by ensuring proper protein integration.
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Protein name
Mitochondrial import inner membrane translocase subunit Tim22
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Uniprot ID
Q9Y584
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Gene Name
TIMM22; TEX4; TIM22
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-73 aa (Q9Y584) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 9.18 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 9 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"