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  • Temporin-1CEa peptide

Temporin-1CEa peptide

Not For Human Use, Lab Use Only.

Cat.#: 303587

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Product Information

  • Product Name
    Temporin-1CEa peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    FVDLKKIANIINSIFGK-NH2
  • Sequence
    H-Phe-Val-Asp-Leu-Lys-Lys-Ile-Ala-Asn-Ile-Ile-Asn-Ser-Ile-Phe-Gly-Lys-NH2
  • Length (aa)
    17
  • Peptide Purity (HPLC)
    95.93%
  • Molecular Formula
    C91H151N23O22
  • Molecular Weight
    1919.33
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Temporin-1CEa is an antimicrobial peptide isolated from the skin secretions of the Chinese brown frog Rana chensinensis. It has the amino acid sequence FVDLKKIANIINSIF-NH2 and shares 50–56% identity with other temporin family peptides from various frog species. Structural analysis reveals that temporin-1CEa adopts a well-defined α-helical conformation in 50% trifluoroethanol/water solution, with an α-helix content of 87.59%. The peptide exhibits amphiphilic properties and a net positive charge, which are characteristic features of membrane-active antimicrobial peptides.

    Studies demonstrate that temporin-1CEa displays cytotoxic effects on multiple human carcinoma cell lines, with particularly high activity against breast cancer MCF-7 cells. The peptide's mechanism of action is attributed to its interaction with negatively charged cell membranes, leading to rapid membrane disruption. Notably, temporin-1CEa shows low hemolytic activity against human erythrocytes and minimal cytotoxicity toward normal human cells, suggesting selective targeting of cancer cell membranes.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Wang C, Li HB, Li S, Tian LL, Shang DJ. Antitumor effects and cell selectivity of temporin-1CEa, an antimicrobial peptide from the skin secretions of the Chinese brown frog (Rana chensinensis). Biochimie. 2012;94(2):434-41.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"