• tau peptide

tau peptide

Not For Human Use, Lab Use Only.

Cat.#: 319216

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Product Information

  • Product Name
    tau peptide
  • Documents
  • Sequence Shortening
    H-TDHGAEIVYK-OH
  • Sequence
    H-Thr-Asp-His-Gly-Ala-Glu-Ile-Val-Tyr-Lys-OH
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    95.62%
  • Molecular Formula
    C50H77N13O17
  • Molecular Weight
    1132.22
  • Source
    Synthetic
  • Form
    Powder
  • Description
    TDHGAEIVYK is 386–395 of tau protein. Aspartic acid isomerization within the tau peptide TDHGAEIVYK was found to be substantially increased in diseased brains. This pathological isomerization, along with proteomic analysis of autophagy markers, has significant implications for an autophagic flux theory of Alzheimer’s disease.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Hubbard EE, Heil LR, Merrihew GE, Chhatwal JP, Farlow MR, McLean CA, Ghetti B, Newell KL, Frosch MP, Bateman RJ, Larson EB, Keene CD, Perrin RJ, Montine TJ, MacCoss MJ, Julian RR. Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer's Disease. J Proteome Res. 2022 Jan 7;21(1):118-131. doi: 10.1021/acs.jproteome.1c00558. Epub 2021 Nov 24. PMID: 34818016; PMCID: PMC8741752.
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"