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  • Tat-βsyn-degron peptide

Tat-βsyn-degron peptide

Not For Human Use, Lab Use Only.

Cat.#: 319101

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Tat-βsyn-degron peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-YGRKKRRQRRRRTKSGVYLVGRRRG-OH
  • Sequence
    H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Thr-Lys-Ser-Gly-Val-Tyr-Leu-Val-Gly-Arg-Arg-Arg-Gly-OH
  • Length (aa)
    25
  • Peptide Purity (HPLC)
    95.06%
  • Molecular Formula
    C132H237N59O31
  • Molecular Weight
    3146.66
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The Tat-syn-degron peptide is a synthetic construct designed to reduce intracellular levels of α-synuclein. It comprises three functional domains: a Tat protein transduction domain that facilitates crossing of the blood-brain barrier and plasma membranes, a β-synuclein-derived sequence that binds specifically to monomeric α-synuclein, and a proteasomal targeting degron signal. This design enables the peptide to bind α-synuclein and direct the complex to the proteasome for degradation.

    Experimental evidence demonstrates that the peptide effectively reduces α-synuclein levels in neuronal cultures and in vivo. The reduction is mediated by the proteasomal pathway, as it is prevented by proteasomal inhibitors. The peptide's action is specific to α-synuclein, as it does not affect levels of related synuclein family members or other unrelated neuronal proteins. The knockdown effect is dose-dependent, time-dependent, and transient, peaking approximately 24 hours after administration.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Jin et al (2021) Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models. Commun. Biol. 4 232 PMID: 33608634
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"