Tat-βsyn-degron peptide

Tat-βsyn-degron peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-YGRKKRRQRRRRTKSGVYLVGRRRG-OH

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Thr-Lys-Ser-Gly-Val-Tyr-Leu-Val-Gly-Arg-Arg-Arg-Gly-OH

25

95.06%

C₁₃₂H₂₃₇N₅₉O₃₁

3146.66

Synthetic

Powder

Tat-βsyn-degron is a blood brain barrier and plasma membrane permeable α-synuclein knockdown peptide which can reduce the level of α-synuclein by proteasomal degradation. Tat-βsyn-degron decreases α-synuclein aggregates and microglial activation in an α-synuclein preformed fibril model of spreading synucleinopathy in transgenic mice overexpressing human A53T α-synuclein, and reduces α-synuclein levels and significantly decreases the neuronal damage and motor impairment in a mouse toxicity model of Parkinsons disease.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Jin et al (2021) Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models. Commun. Biol. 4 232 PMID: 33608634

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.