TAT-obestatin peptide

TAT-obestatin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-RKKRRQRRRFNAPFDVGIKLSGVQYQQHSQAL-NH2

H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu-NH2

32

95.88%

C₁₆₉H₂₈₀N₆₂O₄₃

3868.4

Synthetic

Powder

Obestatin is a 23-amino-acid peptide originally regarded as an anorexigenic factor. Obestatin is incapable of crossing the blood brain barrier (BBB), which may affect its biological function. TAT-obestatin is composed of TAT (is capable of delivering different types of proteins through the BBB.) and obestatin. TAT-obestatin might play a role in white adipose tissue metabolism, but its physiological effects on food intake and body weight gain regulation remain unclear.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Ren G, He Z, Cong P, Chen H, Guo Y, Yu J, Liu Z, Ji Q, Song Z, Chen Y. Peripheral administration of TAT-obestatin can influence the expression of liporegulatory genes but fails to affect food intake in mice. Peptides. 2013 Apr;42:8-14. doi: 10.1016/j.peptides.2013.01.004. Epub 2013 Jan 9. PMID: 23313740.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.