TAT-IKIP (46-60) peptide

TAT-IKIP (46-60) peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-YGRKKRRQRRRLLSLAMTLGLAWLVF-OH

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Leu-Ser-Leu-Ala-Met-Thr-Leu-Gly-Leu-Ala-Trp-Leu-Val-Phe-OH

26

95.85%

C₁₄₅H₂₄₆N₄₈O₃₁S

3189.86

Synthetic

Powder

F1 is a peptide derived from amino acids 46-60 of IkB kinase (IKK) interacting protein (IKIP) fused to a TAT cell penetrating peptide. F1 peptide specifically interacts with IKKalpha/beta to block association with the regulatory subunit NEMO, also known as IKKgamma, thereby inhibiting the phosphorylation of IKKalpha/beta and the activation of NF-kB. F1 reduces LPS induced acute inflammation and attenuates Zymosan-induced acute arthritis in mice.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Liu et al (2021) A Peptide Derived from IKK-Interacting Protein Attenuates NF-κB Activation and Inflammation. J Immunol. Aug 23 ji2100397 Epub ahead of print PMID: 34426543

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.