Tachyplesin III peptide

Tachyplesin III peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-KWCFRVCYRGICYRKCR-NH2 (Disulfide Bonds Between Cys3-Cys16, Cys7-Cys12)

H-Lys-Trp-Cys-Phe-Arg-Val-Cys-Tyr-Arg-Gly-Ile-Cys-Tyr-Arg-Lys-Cys-Arg-NH2 (Disulfide Bonds Between Cys3-Cys16, Cys7-Cys12)

17

95.14%

C₉₉H₁₅₅N₃₃O₁₉S₄

2239.75

Synthetic

Powder

Tachyplesin III (KWCFRVCYRGICYRKCR-NH2), which is derived from horseshoe crabs and exhibits antimicrobial activity against P. aeruginosa. After implantation of the Tachyplesin III-coated stent, P. aeruginosa was injected onto the implant surface. The Tachyplesin-III-treated group showed a reduction in bacterial count compared to uncoated stents, and this effect was further enhanced by co-treatment with intraperitoneal injection of piperacillin-tazobactam (TZP)

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Minardi, D., Ghiselli, R., Cirioni, O., Giacometti, A., Kamysz, W., Orlando, F., Silvestri, C., Parri, G., Kamysz, E., Scalise, G., Saba, V., and Giovanni, M. (2007) The Antimicrobial Peptide Tachyplesin III Coated Alone and in Combination with Intraperitoneal Piperacillin- Tazobactam Prevents Ureteral Stent Pseudomonas Infection in a Rat Subcutaneous Pouch Model. Peptides 28, 2293-2298.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.