Recombinant TAB3 protein (His tag)

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Recombinant Human TAB3 Protein Fragment (residues 509-616) is a high-purity, soluble protein fragment derived from TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. This fragment has been computationally optimized for stability and solubility, making it an ideal tool for structural studies, biochemical assays, and investigating the mechanisms of JNK and NF-kappa-B signaling pathways.

TAB3 (TGF-beta-activated kinase 1-binding protein 3) is a critical adapter protein in human cells that activates the JNK and NF-kappa-B signaling pathways through specific recognition of 'Lys-63'-linked polyubiquitin chains via its RanBP2-type zinc finger (NZF) domain. It functions as a molecular scaffold linking MAP3K7/TAK1 and TRAF6 to ubiquitin chains, facilitating the organization of large signaling complexes that promote autophosphorylation of MAP3K7/TAK1 and subsequent activation of the I-kappa-B-kinase (IKK) core complex. This protein plays essential roles in immune response and cellular signaling regulation, with isoform 2 potentially having oncogenic properties. The provided fragment (residues 509-616) represents a stable, soluble region selected for experimental applications without containing known functional domains.