T7 peptide

T7 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-HAIYPRH-OH

H-His-Ala-Ile-Tyr-Pro-Arg-His-OH

7

98.43%

C₄₁H₆₀N₁₄O₉

893

Synthetic

Powder

T7 (HAIYPRH) peptide, a phage display-selected peptide, exhibited high binding affinity to transferrin receptor (TfR) overexpressed on tumor cells. The binding site of T7 to TfR is distinct from that of Tf, thus avoiding competitive inhibition by endogenous Tf. Moreover, endogenous Tf could facilitate the internalization of T7. T7 demonstrated potential ability as an active targeting ligand for the delivery of agents to TfR-overexpressed tumor cells.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Lee JH, Engler JA, Collawn JF, Moore BA, Receptor mediated uptake of peptides that bind the human transferrin receptor, Eur J Biochem. 268 (2001) 2004-2012.
• Oh S, Kim BJ, Singh NP, Lai H, Sasaki T, Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide, Cancer Lett. 274 (2009) 33-39.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.