T2 peptide

T2 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-LVGVFH-OH

H-Leu-Val-Gly-Val-Phe-His-OH

6

95.47%

C₃₃H₅₀N₈O₇

670.8

Synthetic

Powder

The T2 peptide (LVGVFH) is a novel peptide that has been identified through screening a phage display peptide library. It has been found to enhance the penetration of bacteriophages across porcine and mouse skin, as well as the penetration of hydrophilic drug molecules such as 5-fluorouracil (5-FU). The T2 peptide interacts with skin lipids to enhance skin penetration, without altering the skin integrity or causing any gross changes in skin morphology. It has been observed that the T2 peptide enhances the partitioning of small molecules with different lipophilicities into the skin, suggesting its potential as a safe and noninvasive peptide for improving the skin penetration of drugs. The T2 peptide has been found to be critical for skin penetration enhancement, with histidine at the c-terminus of the peptide playing a key role.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Kumar S, Sahdev P, Perumal O, Tummala H. Identification of a novel skin penetration enhancement peptide by phage display peptide library screening. Mol Pharm. 2012 May 7;9(5):1320-30. doi: 10.1021/mp200594z. Epub 2012 Apr 16. PMID: 22452335.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.