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Recombinant SYT7 protein (His tag)

Cat.#: 537229

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Product Information

  • Product Name
    Recombinant SYT7 protein (His tag)
  • Documents
  • Description

    Recombinant Human Synaptotagmin-7 (SYT7) Fragment (aa 135-403) is a high-purity protein encompassing both C2 domains (C2-1 and C2-2), essential for calcium and phospholipid binding. This fragment serves as an ideal tool for investigating Ca²⁺-dependent exocytosis, membrane fusion mechanisms, and synaptic facilitation in neurological and secretory research applications.

    Synaptotagmin-7 (SYT7) is a high-affinity calcium sensor that plays a critical role in Ca²⁺-triggered exocytosis of synaptic vesicles, lysosomes, and secretory granules. It regulates key processes including synaptic facilitation, plasma membrane repair, phagocytosis, bone remodeling, and hormone secretion by binding to phospholipid membranes and SNARE complexes via its C2 domains. The protein localizes to multiple membranes including the presynaptic membrane, synaptic vesicles, lysosomes, phagosomes, and peroxisomes, with its lysosomal targeting dependent on N-terminal palmitoylation and CD63 interaction. Its involvement in Trypanosoma cruzi cell invasion and cholesterol transport between organelles further highlights its multifunctional significance in cellular physiology.

  • Protein name
    Synaptotagmin-7
  • Uniprot ID
    O43581
  • Gene Name
    SYT7; PCANAP7
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 135-403 aa (O43581) were fused with C-terminal 6His tag.
  • Sequence 
    MNHKVNLGRI QFSVGYNFQE STLTVKIMKA QELPAKDFSG TSDPFVKIYL LPDKKHKLET KVKRKNLNPH WNETFLFEGF
PYEKVVQRIL YLQVLDYDRF SRNDPIGEVS IPLNKVDLTQ MQTFWKDLKP CSDGSGSRGE LLLSLCYNPS ANSIIVNIIK
ARNLKAMDIG GTSDPYVKVW LMYKDKRVEK KKTVTMKRNL NPIFNESFAF DIPTEKLRET TIIITVMDKD KLSRNDVIGK
IYLSWKSGPG EVKHWKDMIA RPRQPVAQWH QLKALEHHHH HH
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 32.83 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 35 kDa band.
  • Purity
    >85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.
  • Validations

    Recombinant SYT7 protein (His tag) SDS-PAGE

    Recombinant SYT7 protein (His tag) SDS-PAGE

    M: Marker; Lane 1: SYT7; Lane 2: BSA

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"