SV peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

• SVVYGLR polypeptide is a synthetic peptide with significant potential in promoting tissue regeneration, particularly in oral and maxillofacial regions.
• Derived from osteopontin, it exhibits angiogenic activity, comparable to that of potent angiogenic factors like VEGF. It induces the differentiation of fibroblasts into myofibroblasts and increases the expression of collagen type III. In vivo, it accelerates dermal and oral mucosal wound healing by enhancing cell motility and migratory activities of fibroblasts and keratinocytes.
• For skeletal muscle regeneration, it promotes cell motility of myogenic cells, facilitates their differentiation, and increases the efficiency of myotube formation. A single dose of this peptide shows potent utility in functional recovery of skeletal muscles after injury, with benefits such as increased muscle fiber diameter and reduced scar tissue formation.
• It likely functions through the TGF-β/Smad signaling pathway, and its short length and unique properties offer advantages like fast metabolism, lower immune response risk, and cost - effectiveness, with potential for developing more effective mutant peptides and various dosage forms.

• Tanaka S, Hamada Y, Yokoyama Y, Yamamoto H, Kogo M. Osteopontin-derived synthetic peptide SVVYGLR upregulates functional regeneration of oral and maxillofacial soft-tissue injury. Jpn Dent Sci Rev. 2021 Nov;57:174-181. doi: 10.1016/j.jdsr.2021.09.002. Epub 2021 Sep 28. PMID: 34630775; PMCID: PMC8487951.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.