Stresscopin-Related Peptide (6-43) (human), Urocortin II

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Stresscopin-Related Peptide (6-43) (human), also known as Urocortin II (Ucn 2), is a 38-amino acid neuropeptide belonging to the corticotropin-releasing factor (CRF) family. It is characterized by its high selectivity for the type 2 CRF receptor (CRF₂), exhibiting approximately 1000-fold greater affinity for CRF₂ over CRF₁ receptors. This peptide does not bind to the human CRF-binding protein.

Central administration of Urocortin II demonstrates specific biological effects, including the suppression of food and water intake in animal models. Its activity profile differs from that of CRF₁ receptor agonists; Ucn 2 reduces intake without inducing behavioral arousal or signs of visceral illness, and under dietary choice conditions, it preferentially reduces consumption of carbohydrate-rich items. Furthermore, it is associated with delayed-onset, non-dose-dependent suppression of motor activity, contrasting with the acute motor-stimulating effects of CRF₁ receptor activation.

• Zorrilla EP, Reinhardt LE, Valdez GR, Inoue K, Rivier JE, Vale WW, Koob GF. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. J Pharmacol Exp Ther. 2004 Sep;310(3):1027-34. doi: 10.1124/jpet.104.068676. Epub 2004 Apr 28. PMID: 15115804.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.