Stigmurin peptide

Stigmurin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

FFSLIPSLVGGLISAFK

Phe-Phe-Ser-Leu-Ile-Pro-Ser-Leu-Val-Gly-Gly-Leu-Ile-Ser-Ala-Phe-Lys

17

96.9%

Synthetic

Powder

APD analysis reveals that the sequence is 88.2% similar to scorpion AMP TsAP-1. Active against S. aureus ATCC 29213 (MIC 8.7 uM), MRSA ATCC 33591 (MIC 17.4 uM), yeasts C. albicans ATCC 90028 (MIC 34.8 uM), C. krusei ATCC 6258, and C. glabrata ATCC 90030 (MIC 69.5 uM). ~50% killing of SiHa cells between 70-140 uM and of Vero E6 cells at ~140 uM. CD curves are helical in TFE. The source of Stigmurin is venom gland, Tityus stigmurus.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• De melo ET, Estrela AB, Santos EC, et al. Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin. Peptides. 2015;

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.