Soymorphin-5 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Soymorphin-5 is a pentapeptide with the amino acid sequence YPFVV. It is derived from the enzymatic digestion of the β-subunit of soybean β-conglycinin. This peptide is characterized as a μ-opioid receptor agonist.

The peptide has been studied in model systems, where it was observed to influence metabolic parameters. Investigations indicate that Soymorphin-5 can modulate the adiponectin signaling pathway, notably increasing the expression of the AdipoR2 receptor subtype. This is associated with subsequent activation of the PPARα system and an upregulation of its target genes involved in fatty acid oxidation, such as acyl-CoA oxidase and carnitine palmitoyltransferase 1A.

• Yamada Y, Muraki A, Oie M, Kanegawa N, Oda A, Sawashi Y, Kaneko K, Yoshikawa M, Goto T, Takahashi N, Kawada T, Ohinata K. Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice. Am J Physiol Endocrinol Metab. 2012 Feb 15;302(4):E433-40.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.