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Product Name
Recombinant SOX2 protein (His tag)
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Description
Recombinant Human SOX-2 (Transcription factor SOX-2) fragment (residues 39-119) is a high-purity, stable protein designed for structural and biochemical studies. This 81-amino acid fragment retains key solubility and stability properties, making it ideal for investigating the molecular mechanisms of SOX-2 in embryonic development and stem cell pluripotency.
Transcription factor SOX-2, encoded by the SOX2 gene in Homo sapiens, is a critical regulator of embryonic development and stem cell pluripotency. It functions by forming a trimeric complex with OCT4 on DNA to control the expression of genes such as YES1, FGF4, UTF1, and ZFP206, and binds to the proximal enhancer region of NANOG. SOX-2 is essential for early embryogenesis and maintaining embryonic stem cell pluripotency, and it also promotes neural stem cell self-renewal by counteracting proneural proteins and suppressing neuronal differentiation, potentially acting as a switch in neuronal development. The protein localizes primarily to the nucleus, including nuclear speckles, with some presence in the cytoplasm. Its nuclear localization is influenced by acetylation, and it interacts with proteins such as ZNF208, SOX6, and CAML, while nuclear import is facilitated by XPO4.
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Protein name
Transcription factor SOX-2
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Uniprot ID
P48431
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Gene Name
SOX2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 39-119 aa (P48431) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 11.57 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 12 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"